PAEA Surgery End Of Rotation (EOR) Practice Exam

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What is the common origin of papillary thyroid cancer?

Follicular cells
C cells
Parafollicular cells
Medullary cells

The correct answer is: Follicular cells

Papillary thyroid cancer develops from follicular cells, which are responsible for producing thyroid hormones. These cells are integral to the structure and function of the thyroid gland. In the case of papillary thyroid cancer, mutations lead to abnormal growth and proliferation of these follicular cells, resulting in the formation of tumors. This cancer type is characterized by its distinctive histological features, including the presence of papillae and nuclear atypia. Follicular cells are found within the thyroid follicles and play a crucial role in the synthesis and secretion of thyroid hormones such as thyroxine (T4) and triiodothyronine (T3). As such, understanding the origin of papillary thyroid cancer in follicular cells emphasizes the relationship between thyroid cellular structure and pathology. The other options refer to different cell types located in the thyroid gland. C cells, also known as parafollicular cells, are involved in producing calcitonin and are not the source of papillary thyroid cancer. Medullary cells are specifically related to medullary thyroid carcinoma, which arises