PAEA Surgery End Of Rotation (EOR) Practice Exam

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Follicular thyroid cancer is notably characterized by:

  1. High calcitonin levels

  2. Advanced stage at diagnosis

  3. Ground glass appearance on imaging

  4. Good response to iodine treatment

The correct answer is: Good response to iodine treatment

Follicular thyroid cancer is characterized by a good response to iodine treatment, particularly radioactive iodine therapy. This cancer type generally arises from follicular cells, which are the thyroid cells responsible for synthesizing thyroid hormones. Because follicular thyroid cancer retains the functionality of these cells, it often takes up radioactive iodine effectively. This treatment can be used both as a therapeutic approach and for ablating any remaining thyroid tissue after surgery. Additionally, the ability of follicular thyroid cancer to absorb iodine is an important factor in its management, leading to a relatively favorable prognosis when appropriately treated. This stands in contrast to medullary thyroid cancer, for example, which is associated with high calcitonin levels. In regard to the other options, while follicular thyroid cancer can indeed be diagnosed at an advanced stage, this varies by case and is not a defining characteristic. The ground glass appearance is more closely associated with papillary thyroid carcinoma rather than follicular thyroid cancer. Therefore, the ability of follicular thyroid cancer to respond positively to iodine treatment is the key feature that is appropriately recognized.